A contribution of cellular immunity to protection against influenza in man
Identifieur interne : 002A24 ( Main/Exploration ); précédent : 002A23; suivant : 002A25A contribution of cellular immunity to protection against influenza in man
Auteurs : R. Jennings [Royaume-Uni] ; R. J. Fenton [Royaume-Uni] ; M. G. Mcentegart [Royaume-Uni] ; C. W. Potter [Royaume-Uni]Source :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 1978-11-01.
English descriptors
- Teeft :
- Allantoic fluids, Antibody, Antibody levels, Antibody response, Antibody rise, Antibody titres, Average migration, Blood samples, Blood specimen, Cellular, Cellular immunity, Challenge infection, Control antigen, Detectable serum, Freestone, Hobson, Hypersensitivity, Hypersensitivity response, Immune, Immune response, Immune responses, Immunity, Immunization, Infection, Influenza, Influenza infection, Influenza virus, Influenza virus antigen, Influenza virus infection, Influenza virus vaccine, Influenza virus vaccines, Influenza viruses, Inoculated, Inoculated intranasally, Inoculation, Intradermal inoculation, Jennings, Leukocyte, Leukocyte migration, Leukocyte migration inhibition, Leukocyte migration inhibition tests, Local antibody, Lymphocyte, Lymphocyte transformation, Lymphocyte transformation tests, Lymphocyte transformations, Medium rpmi, Migration, Nasal, Nasal secretions, Nasal wash, Nasal washings, Present study, Reaction area, Serological tests, Serum antibody, Serum antibody level, Several studies, Skin tests, Stimulation indices, Titre, Vaccine, Virus, Virus infection, Virus inoculation, Virus isolation, Virus vaccine, Volunteer, Volunteers number, Volunteers volunteers, Waldman.
Abstract
Abstract: The degree of lymphocyte transformations and leukocyte migration inhibition (LMI) in the presence of inactivated A/Scotland/74 (H3N2) influenza virus vaccine was measured in blood samples collected from 56 medical student volunteers. At the same time the volunteers were skin tested, using the same vaccine. Using the antigenically similar WRL 105 (H3N2), recombinant influenza virus, the level of haemagglutination-inhibiting (HI) antibodies in serum, and neutralizing antibodies in nasal washings collected from the volunteers, were also determined. Each volunteer was then inoculated with live, attenuated WRL 105 influenza virus vaccine and infections demonstrated by virus isolations and serology. Correlations between the ability to infect the volunteers and the various parameters of humoral and cellular immunity were then determined. The results showed a good correlation between the level of serum HI antibody and infection. Thus 16 of 20 volunteers with serum HI antibody titres of 1∶10, but only 6 of 20 volunteers with antibody levels of 1∶30, showed evidence of infection. No direct correlation was observed between any of the other parameters measured and infection by WRL 105 virus. However, when the LMI and serum HI antibody levels were considered together, a contribution of cellular immunity, as measured by the LMI test, could be found. Of 19 volunteers with low serum HI antibody and low LMI levels, 16 were infected, whereas of 13 volunteers with low HI antibody, but with high LMI levels, only 6 showed evidence of infection with WRL 105 influenza virus.
Url:
DOI: 10.1007/BF02121134
Affiliations:
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Jennings</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Departments of Virology and Medical Microbiology, Academic Division of Pathology, University of Sheffield Medical School, Sheffield</wicri:cityArea></affiliation></author><author><name sortKey="Fenton, R J" sort="Fenton, R J" uniqKey="Fenton R" first="R. J." last="Fenton">R. J. Fenton</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Departments of Virology and Medical Microbiology, Academic Division of Pathology, University of Sheffield Medical School, Sheffield</wicri:cityArea></affiliation></author><author><name sortKey="Mcentegart, M G" sort="Mcentegart, M G" uniqKey="Mcentegart M" first="M. G." last="Mcentegart">M. G. Mcentegart</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Departments of Virology and Medical Microbiology, Academic Division of Pathology, University of Sheffield Medical School, Sheffield</wicri:cityArea></affiliation></author><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Departments of Virology and Medical Microbiology, Academic Division of Pathology, University of Sheffield Medical School, Sheffield</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical Microbiology and Immunology</title><title level="j" type="abbrev">Med Microbiol Immunol</title><idno type="ISSN">0300-8584</idno><idno type="eISSN">1432-1831</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1978-11-01">1978-11-01</date><biblScope unit="volume">166</biblScope><biblScope unit="issue">1-4</biblScope><biblScope unit="page" from="51">51</biblScope><biblScope unit="page" to="62">62</biblScope></imprint><idno type="ISSN">0300-8584</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-8584</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Allantoic fluids</term><term>Antibody</term><term>Antibody levels</term><term>Antibody response</term><term>Antibody rise</term><term>Antibody titres</term><term>Average migration</term><term>Blood samples</term><term>Blood specimen</term><term>Cellular</term><term>Cellular immunity</term><term>Challenge infection</term><term>Control antigen</term><term>Detectable serum</term><term>Freestone</term><term>Hobson</term><term>Hypersensitivity</term><term>Hypersensitivity response</term><term>Immune</term><term>Immune response</term><term>Immune responses</term><term>Immunity</term><term>Immunization</term><term>Infection</term><term>Influenza</term><term>Influenza infection</term><term>Influenza virus</term><term>Influenza virus antigen</term><term>Influenza virus infection</term><term>Influenza virus vaccine</term><term>Influenza virus vaccines</term><term>Influenza viruses</term><term>Inoculated</term><term>Inoculated intranasally</term><term>Inoculation</term><term>Intradermal inoculation</term><term>Jennings</term><term>Leukocyte</term><term>Leukocyte migration</term><term>Leukocyte migration inhibition</term><term>Leukocyte migration inhibition tests</term><term>Local antibody</term><term>Lymphocyte</term><term>Lymphocyte transformation</term><term>Lymphocyte transformation tests</term><term>Lymphocyte transformations</term><term>Medium rpmi</term><term>Migration</term><term>Nasal</term><term>Nasal secretions</term><term>Nasal wash</term><term>Nasal washings</term><term>Present study</term><term>Reaction area</term><term>Serological tests</term><term>Serum antibody</term><term>Serum antibody level</term><term>Several studies</term><term>Skin tests</term><term>Stimulation indices</term><term>Titre</term><term>Vaccine</term><term>Virus</term><term>Virus infection</term><term>Virus inoculation</term><term>Virus isolation</term><term>Virus vaccine</term><term>Volunteer</term><term>Volunteers number</term><term>Volunteers volunteers</term><term>Waldman</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The degree of lymphocyte transformations and leukocyte migration inhibition (LMI) in the presence of inactivated A/Scotland/74 (H3N2) influenza virus vaccine was measured in blood samples collected from 56 medical student volunteers. At the same time the volunteers were skin tested, using the same vaccine. Using the antigenically similar WRL 105 (H3N2), recombinant influenza virus, the level of haemagglutination-inhibiting (HI) antibodies in serum, and neutralizing antibodies in nasal washings collected from the volunteers, were also determined. Each volunteer was then inoculated with live, attenuated WRL 105 influenza virus vaccine and infections demonstrated by virus isolations and serology. Correlations between the ability to infect the volunteers and the various parameters of humoral and cellular immunity were then determined. The results showed a good correlation between the level of serum HI antibody and infection. Thus 16 of 20 volunteers with serum HI antibody titres of 1∶10, but only 6 of 20 volunteers with antibody levels of 1∶30, showed evidence of infection. No direct correlation was observed between any of the other parameters measured and infection by WRL 105 virus. However, when the LMI and serum HI antibody levels were considered together, a contribution of cellular immunity, as measured by the LMI test, could be found. Of 19 volunteers with low serum HI antibody and low LMI levels, 16 were infected, whereas of 13 volunteers with low HI antibody, but with high LMI levels, only 6 showed evidence of infection with WRL 105 influenza virus.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name></region><name sortKey="Fenton, R J" sort="Fenton, R J" uniqKey="Fenton R" first="R. J." last="Fenton">R. J. Fenton</name><name sortKey="Mcentegart, M G" sort="Mcentegart, M G" uniqKey="Mcentegart M" first="M. G." last="Mcentegart">M. G. Mcentegart</name><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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